A Novel Skin Barrier Protectant for Acute Radiodermatitis

Inclusion Criteria: * Diagnosis of head and neck squamous cell carcinomas (HNSCC) starting in the lip, salivary gland, oral cavity (mouth), nasal cavity (inside the nose), paranasal sinuses, pharynx, or larynx. * Scheduled for bilateral neck radiotherapy (\>60 Gy) with or without concomitant chemotherapy either as primary or as post-operative treatment to the head and neck region * Age ≥ 18 years * Able to comply to the study protocol * Able to sign written informed consent * Signed written informed consent Exclusion Criteria: * Previous irradiation to the head and/or neck region * Metastatic disease * Patients with pre-existing skin rash, ulceration or open wound in the treatment area * Patients with known allergic and other systemic skin diseases even when not directly affecting irradiated fields * Substance abuse patients or patients with medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results as judged by the investigator * Any condition that is unstable or could affect the safety of the patient and their compliance in the study as judged by the investigator * Patients using high doses of non-steroidal anti-inflammatory drugs * Patients allergic to the ingredients of the 3M™ Cavilon™ Advanced Skin Protectant