UnknownNot Applicable

Effect of Double Antibiotic Paste Versus Calcium Hydroxide on RANKL/OPG Levels

50 participantsStarted 2020-11

Plain-language summary

The aim of the present study is to evaluate the effect of double antibiotic paste when compared to Ca (OH)2, in terms of RANKL and OPG levels in chronic periapical lesions and correlate the results with periapical bone healing findings after a follow up period of one year.

Who can participate

Age range

20 Years – 45 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients who are free from any physical or mental handicapping conditions and with no underlying systemic diseases. * Age between 20-45years old. * Males \& Females. * Single canaled teeth: * Diagnosed clinically with asymptomatic apical periodontitis. * Absence of spontaneous pain * Size of periapical radiolucency: 2-4 mm (i.e. score 3 according to CBCT periapical index proposed by Estrela)30, including only the tested tooth. * Patients who didn't use any NSAIDs or antibiotics for 1 month before treatment. * Patients' acceptance to participate in the trial. Exclusion Criteria: * \- Medically compromised patients. * Pregnant women. * Patients reporting bruxism or clenching. * Patients allergic to ciprofloxacin or metronidazole. * Teeth associated with acute periapical abscess and/or swelling. * Greater than grade I mobility or pocket depth greater than 5mm. * Size of periapical radiolucency is less than 2 mm or greater than 4 mm. * Non restorable teeth. * Immature teeth. * Radiographic evidence of external or internal root resorption vertical root fracture, perforation, calcification.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Percentage change of RANKL/OPG levels

Timeframe: measured Immediately post-instrumentation and after one week

Trial details

NCT IDNCT04593238

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-04

View on ClinicalTrials.gov More Biological Markers trials

Who can participate

Age range

20 Years – 45 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.