Effect of Double Antibiotic Paste Versus Calcium Hydroxide on RANKL/OPG Levels (NCT04593238) | Clinical Trial Compass
UnknownNot Applicable
Effect of Double Antibiotic Paste Versus Calcium Hydroxide on RANKL/OPG Levels
50 participantsStarted 2020-11
Plain-language summary
The aim of the present study is to evaluate the effect of double antibiotic paste when compared to Ca (OH)2, in terms of RANKL and OPG levels in chronic periapical lesions and correlate the results with periapical bone healing findings after a follow up period of one year.
Who can participate
Age range20 Years – 45 Years
SexALL
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Inclusion Criteria:
* Patients who are free from any physical or mental handicapping conditions and with no underlying systemic diseases.
* Age between 20-45years old.
* Males \& Females.
* Single canaled teeth:
* Diagnosed clinically with asymptomatic apical periodontitis.
* Absence of spontaneous pain
* Size of periapical radiolucency: 2-4 mm (i.e. score 3 according to CBCT periapical index proposed by Estrela)30, including only the tested tooth.
* Patients who didn't use any NSAIDs or antibiotics for 1 month before treatment.
* Patients' acceptance to participate in the trial.
Exclusion Criteria:
* \- Medically compromised patients.
* Pregnant women.
* Patients reporting bruxism or clenching.
* Patients allergic to ciprofloxacin or metronidazole.
* Teeth associated with acute periapical abscess and/or swelling.
* Greater than grade I mobility or pocket depth greater than 5mm.
* Size of periapical radiolucency is less than 2 mm or greater than 4 mm.
* Non restorable teeth.
* Immature teeth.
* Radiographic evidence of external or internal root resorption vertical root fracture, perforation, calcification.
What they're measuring
1
Percentage change of RANKL/OPG levels
Timeframe: measured Immediately post-instrumentation and after one week