UnknownNot Applicable

Misoprostol With or Without Letrozole in Treatment of Missed Miscarriage

Egypt320 participantsStarted 2019-01-15

Plain-language summary

Aim of study Compare the success rate of misoprostol with versus without letrozole as a pretreatment for medical termination of pregnancy during the first trimester. Hypothesis: Letrozole value as a pre-treatment medication for misoprostol in induction of abortion during the first trimester. Research question: Will letrozole- misoprostol protocol give better results than misoprostol- alone protocol in induction of abortion during the first trimester?

Who can participate

Age range

18 Years – 35 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Woman age more than 18 years old (age of legal consent). * BMI ranges between 25 kg/m2 and 35 kg/m2. * Gestational age of 63 days' gestation (or less). * Missed abortion. * Hemoglobin leve Exclusion criteria: * Woman age less than 18 years old. * BMI less than 25 kg/m2 or more than 35 kg/m2. * Gestational age more than 63 days' gestation. * Molar pregnancy. * Hemoglobin level less than 10 gm/dL. * Fibroid uterus. * Uterus with congenital anomalies. * Previous attempts for induction of abortion in the current pregnancy. * Coagulation defect i.e. coagulopathy. * Contraindication for induction of abortion e.g. heart failure. * Allergy to misoprostol or letrozole.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Complete abortion

Timeframe: 1week

Trial details

NCT IDNCT04593108

SponsorDr.Dalia Mohammed Al Sayed Zaki

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-10-01

View on ClinicalTrials.gov More Missed Abortion trials