Active — Not RecruitingNot Applicable

Cardiovascular and Neurovascular Regulation in GWI

United States70 participantsStarted 2023-05-16

Plain-language summary

Brain blood flow regulation and autonomic dysfunction will be measured in Veterans with and without Gulf War Illness who served in the Gulf War between 1990 and 1992.

Who can participate

Age range45 Years – 68 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Deployed to the Persian Gulf between 1990-1992 * Body mass \<300 lbs * Diagnosis of Gulf War Illness based on CMI/CDC and Kansas definitions or No diagnosis of Gulf War Illness Exclusion Criteria: * Current or lifetime evidence of: Type II diabetes, neurological disease, cancer treatment, rheumatoid arthritis, lupus, bipolar disorder, psychotic disorders, or mood disorders with psychotic features * Current illicit substance use or partial remission for less than 1 year * Taking multiple sedatives or anticonvulsant medications * Currently pregnant * Absolute contraindications to exercise testing * Contraindications to MRI * Other significant medical conditions at investigator's discretion

What they're measuring

Brain blood flow measured using Transcranial Doppler ultrasound

Timeframe: Baseline

Brain blood flow measured using MRI

Timeframe: Baseline

Sympathetic nerve activity

Timeframe: Baseline

Trial details

NCT IDNCT04586049

SponsorUniversity of Wisconsin, Madison

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-06

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