Cardiovascular and Neurovascular Regulation in GWI (NCT04586049) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Cardiovascular and Neurovascular Regulation in GWI
United States70 participantsStarted 2023-05-16
Plain-language summary
Brain blood flow regulation and autonomic dysfunction will be measured in Veterans with and without Gulf War Illness who served in the Gulf War between 1990 and 1992.
Who can participate
Age range
45 Years – 68 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Deployed to the Persian Gulf between 1990-1992
* Body mass \<300 lbs
* Diagnosis of Gulf War Illness based on CMI/CDC and Kansas definitions or No diagnosis of Gulf War Illness
Exclusion Criteria:
* Current or lifetime evidence of: Type II diabetes, neurological disease, cancer treatment, rheumatoid arthritis, lupus, bipolar disorder, psychotic disorders, or mood disorders with psychotic features
* Current illicit substance use or partial remission for less than 1 year
* Taking multiple sedatives or anticonvulsant medications
* Currently pregnant
* Absolute contraindications to exercise testing
* Contraindications to MRI
* Other significant medical conditions at investigator's discretion
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is studying brain blood flow and sympathetic nerve activity in Gulf War Illness — given that it's no longer recruiting new participants, is there any similar study currently open that I might be considered for?
2The trial measures brain blood flow using both Transcranial Doppler ultrasound and MRI — what do these tests actually involve for me physically, and are there any risks or discomforts I should know about before deciding whether to participate in something like this?
3Since this study is listed as 'Phase NA,' which often means it's focused on understanding a condition rather than testing a treatment, should I also be exploring standard-of-care options for my symptoms at the same time rather than waiting for findings from observational research like this?
4The trial focuses on neurovascular control and sympathetic nerve activity — do my specific cardiovascular or neurological symptoms match the kind of patients this research was designed to study, and would my doctor recommend I try to connect with the research team even at this late stage?
5Are there any results or published findings from this trial that my doctor could review, so we can discuss whether the emerging science on brain blood flow in Gulf War Illness might change how my symptoms are being evaluated or managed?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Brain blood flow measured using Transcranial Doppler ultrasound