Active — Not RecruitingPhase 2

Dual Intravitreal Implantation of NT-501 Encapsulated Cell Therapy for Glaucoma

United States30 participantsStarted 2021-05-15

Plain-language summary

To determine the safety and efficacy over 24 months of dual NT-501 CNTF encapsulated cell therapy (ECT) on visual impairment related to glaucoma.

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Participant must be medically able to undergo the testing required in the schedule of events (SOE).
✓. Participant's clinical diagnosis must be consistent with glaucoma characterized by the following features: Mean deviation (MD) of -3 to -20 dB on Humphrey Visual Field 24-2 testing and two visual field tests of adequate quality with a maximum VFI variability of ± 10%
✓. Residual visual field preservation including best-corrected visual acuity (BCVA) better than 20/200 in either eye.
✓. Participant's eye pressure must be clinically stable, with IOP \<21.
✓. If a participant has two eyes meeting study criteria, the worse eye as determined by visual field index (VFI) or patient preference, will be deemed includable. If both eyes qualify and have the same VFI, a randomization procedure will assign one eye to the study.
✓. Participant must understand and sign the informed consent. If the participant's vision is impaired to the point where he/she cannot read the informed consent document, the document will be read to the participant in its entirety.
✓. Females of childbearing potential must agree to use an effective form of birth control.
✓. Participant must be determined by the presurgical anesthesia or medical team to be fit for ophthalmic surgery for the NT-501 ECT implant insertion.

✕. Participant is unable to comply with study procedures or followup visits.
✕. Participant has other optic nerve or retinal degenerative disease causing vision loss, irrespective of whether it is currently treated or untreated.
✕. Participant is likely to be offered glaucoma surgery in the study eye within 6 months of screening.
✕. Participant has cataract-associated vision loss to less than 20/40.
✕. Participant has a history of ocular herpes zoster.
✕. Participant has a requirement of acyclovir and/or related products during study duration. To be eligible for this study, the participant must discontinue use of these products prior to enrollment and must not continue with the products until after they have completed the study.
✕. Participant has evidence of corneal opacification or lack of optical clarity.
✕. Participant has uveitis or other ocular inflammatory disease.

Visual Field MD at 12 Months

Timeframe: 12 months

NCT IDNCT04577300

SponsorStanford University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-08-15

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Participant must be medically able to undergo the testing required in the schedule of events (SOE).
✓. Participant's clinical diagnosis must be consistent with glaucoma characterized by the following features: Mean deviation (MD) of -3 to -20 dB on Humphrey Visual Field 24-2 testing and two visual field tests of adequate quality with a maximum VFI variability of ± 10%
✓. Residual visual field preservation including best-corrected visual acuity (BCVA) better than 20/200 in either eye.
✓. Participant's eye pressure must be clinically stable, with IOP \<21.
✓. If a participant has two eyes meeting study criteria, the worse eye as determined by visual field index (VFI) or patient preference, will be deemed includable. If both eyes qualify and have the same VFI, a randomization procedure will assign one eye to the study.
✓. Participant must understand and sign the informed consent. If the participant's vision is impaired to the point where he/she cannot read the informed consent document, the document will be read to the participant in its entirety.
✓. Females of childbearing potential must agree to use an effective form of birth control.
✓. Participant must be determined by the presurgical anesthesia or medical team to be fit for ophthalmic surgery for the NT-501 ECT implant insertion.

✕. Participant is unable to comply with study procedures or followup visits.
✕. Participant has other optic nerve or retinal degenerative disease causing vision loss, irrespective of whether it is currently treated or untreated.
✕. Participant is likely to be offered glaucoma surgery in the study eye within 6 months of screening.
✕. Participant has cataract-associated vision loss to less than 20/40.
✕. Participant has a history of ocular herpes zoster.
✕. Participant has a requirement of acyclovir and/or related products during study duration. To be eligible for this study, the participant must discontinue use of these products prior to enrollment and must not continue with the products until after they have completed the study.
✕. Participant has evidence of corneal opacification or lack of optical clarity.
✕. Participant has uveitis or other ocular inflammatory disease.