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SporTRIA Study: A Multicentre Trial for Excretion Kinetics of Triamcinolone Acetonide Following Sport Related Intra-articular Injections in Knees; Definitions of the Washout Periods

France20 participantsStarted 2023-01-01

Plain-language summary

Intra-articular and peri-articular glucocorticoid (GC) injections are common in sports medicine. However, from 1st January 2022, all injectable GC routes (including intra-articular administration (IA)) will be prohibited in-competition by World Anti-Doping Agency (WADA). Due to these rules, an IA GC treatment out-of-competition could result in an adverse analytical finding (AAF) in-competition if the washout period is not clearly defined. The aim of this study is to determine the urinary excretion profile of triamcinolone acetonide following IA to help in the definition of the washout periods.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Sports practice at least 4h / week * No comorbidities against indicating intra-articular knee injection * Subject with a knee disease requiring intra-articular injection of GCs Exclusion Criteria: * Subject with glucocorticoid (GC) allergy or GC medical contraindication * Pregnant women or women of childbearing potential without effective contraception * Washout period of all injectable routes and systemic use of GCs less than 3 months

What they're measuring

Determination of the excretion profile of triamcinolone acetonide in urine following intra-articular ultrasound-guided injection

Timeframe: Change from baseline, pre-injection (day 0) to date (up to 35 days) where glucocorticoids urinary value below the 15 ng/ml

Trial details

NCT IDNCT04574232

SponsorCentral Hospital, Nancy, France

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-12-01

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