CompletedNot Applicable

Sleep Spindles and Memory in Rolandic Epilepsy

United States30 participantsStarted 2021-01-16

Plain-language summary

The investigators are recruiting children with Rolandic epilepsy and children without epilepsy (aged 4 years old and above) for a non-invasive brain imaging study using Magnetic Resonance Imaging (MRI), Magnetoencephalography/Electroencephalography (MEG/EEG), and experimental tasks. The investigators hope to determine the brain circuits and brain rhythms affected in these children and ultimately identify new treatment options for childhood epilepsy patients.

Who can participate

Age range4 Years – 18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Ages 4-18 years
✓. Diagnosed with childhood epilepsy with centrotemporal spikes (CECTS) or Rolandic epilepsy by child neurologist
✓. Has EEG with sleep activated centrotemporal spikes
✓. Has had at least 1 focal motor or generalized seizure

Exclusion criteria

✕. Has abnormal brain MRI
✕. Has other unrelated neurological disease
✕. Unable to have an MRI/MEG
✕. Claustrophobic
✕. History of frequent vomiting
✕. Permanent metal in body, braces
✕. Over MRI weight limit: 350lbs

What they're measuring

Spindle Density

Timeframe: 1-5 hours

Memory performance

Timeframe: 1-5 hours

Trial details

NCT IDNCT04569708

SponsorMassachusetts General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-06-30

View on ClinicalTrials.gov More Rolandic Epilepsy trials