Prevention of Hand-foot Skin Reaction

Inclusion Criteria: * HCC by proof of pathology * Presence of tumor thrombus in the main trunk of the portal vein or the first-order branches of the portal vein with minimal ascetics or with no ascetics by abdominal CT scan * Child-Pugh liver function class A * Planning to receive oral sorafenib 400 mg twice per day * Age of 20 or more years old * Able to communication in Chinese, Taiwanese or Hakka Exclusion Criteria: * Encephalopathy, psychosis, cognition impairment, blindness or hearing impairment * Allergic history to urea * Present ulceration, blisters, infective problems on the palms or soles * Previous surgery, systematic chemotherapy or frequent radial ablation