This study will investigate the effect of exercise training on 24h rhythms in substrate metabolism in overweight subjects with impaired glucose tolerance. Subjects will perform exercise training for 12 weeks. Before and after the exercise period, they will be admitted to research facilities for 45 hours to assess 24h rhythms in substrate metabolism. In a single-arm longitudinal design, subjects will serve as their own control.
Age range
40 Years – 75 Years
Sex
MALE
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Change in 24 rhythm in whole-body energy metabolism (energy expenditure)
Timeframe: measured at 8:00, 13:00, 18:00, 23:00, 04:00 of the main test day before and after 12 weeks of exerise
Change in 24 rhythm in whole-body energy metabolism (glucose oxidation)
Timeframe: measured at 8:00, 13:00, 18:00, 23:00, 04:00 of the main test day before and after 12 weeks of exercise
Change in 24 rhythm in whole-body energy metabolism (fat oxidation)
Timeframe: measured at 8:00, 13:00, 18:00, 23:00, 04:00 of the main test day before and after 12 weeks of exercise