CompletedNot Applicable

Association Between Fuchs' Endothelial Corneal Dystrophy Severity and Estrogen Exposure

United States43 participantsStarted 2018-01-17

Plain-language summary

This study is being done to discover if there is a link between estrogen exposure and the severity of Fuchs Endothelial Corneal Disease. We are trying to understand if the decrease in estrogen levels in post-menopausal women may be a reason why FECD is seen more often in women than men.

Who can participate

Age range55 Years

SexALL

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Inclusion criteria

✓. Individuals with FECD grade 1-2/7 (mild) or 5-6/7 (severe) in one or both eyes
✓. Age ≥ 55
✓. Phakic and pseudophakic individuals will be included. Pseudophakic patients must have evidence of routine cataract surgery (posterior chamber intraocular lens in-the-bag without clinical evidence of damage to any intraocular structures).

Exclusion criteria

✕. Females are excluded if not post-menopause.
✕. Pseudophakic patients with a history of complex cataract surgery or other intraocular surgery (e.g. have an anterior chamber lens, sulcus lens, or poorly positioned posterior chamber lens, aphakia, iris damage, glaucoma surgery) will be excluded due to risk of iatrogenic damage to the corneal endothelium.

What they're measuring

Association Between Fuchs endothelial Corneal Dystophy Severity and Estrogen Exposure

Timeframe: 5 years

Trial details

NCT IDNCT04564378

SponsorState University of New York at Buffalo

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-04-27

View on ClinicalTrials.gov More Fuchs Dystrophy trials