COVID-19 Serology and Immunosenescence (NCT04563650) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
COVID-19 Serology and Immunosenescence
France98 participantsStarted 2020-08-29
Plain-language summary
This study aims to determine how long COVID-19 neutralizing antibodies can be detected in an elderly institutionalized population presenting fragility factors.
This study also aims to stratify seroconversion by immunological profiles of the elderly patients residing in the EHPAD. This stratification requires the measurement of immunological marker levels already described in immunosenescence and also involved in the development of certain chronic infectious diseases more common in the elderly population. This analysis will enable the investigators to describe an immunological, clinical and biological profile representing a patient who has developed an immunity against COVID 19. It will also help the investigators to understand the different mechanisms leading to a reduced immune response after a potential administration of a vaccine. Finally, it will help describe the immune profiles of elderly residents who presented with non-severe forms of COVID-19.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Residents of the EHPAD/USLD St Victor of the Amiens CHU who took part in the screening campaign (RT-PCR and serology) organized by the Amiens CHU
* residents who signed a consent form to participate in the study
Exclusion Criteria:
* The patient or his legal representative refused to participate in the study
* Heavily sedated patients
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study is looking at how older adults' immune systems respond to COVID-19 by measuring neutralizing antibody levels — given my age and health situation, could the findings from a study like this affect how my doctor thinks about my own COVID-19 immunity or vaccination timing?
2Since this trial is no longer enrolling new participants, are there any similar ongoing studies on COVID-19 immunity and aging that I might still be eligible to join?
3The study focuses on 'immunosenescence,' which is how the immune system weakens with age — is this something my doctor has already factored into my COVID-19 protection plan, and should we be doing any antibody testing to check my own response?
4Because this is a Phase NA observational study measuring antibody titers rather than testing a treatment, does participating in or following research like this change any actual care decisions, or is it more about contributing data for future use?
5Given that this research is specifically about older adults and COVID-19 immune response, what does my doctor currently know about how well I'm protected against COVID-19, and would additional antibody testing be worthwhile in my case?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.