Representational Approach to Hippocampal Functions : a fMRI Study (NCT04562974) | Clinical Trial Compass
CompletedNot Applicable
Representational Approach to Hippocampal Functions : a fMRI Study
France60 participantsStarted 2021-09-03
Plain-language summary
Although traditional neuropsychological models associate medial temporal lobe (MTL) regions to memory, and the hippocampus to episodic memory, there is growing evidence supporting an alternative view. The representational view of the MTL proposes that such regions depends on the representations processed rather than the cognitive processes. The aim of this project is to characterise the role played by MTL areas, and particularly the hippocampus, in mnemonic and non-mnemonic cognition. Hypotheses stemming from the representational view will thus be tested, using functional MRI among young healthy participants.
Who can participate
Age range
18 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Affiliation to French Healthcare system
* No contraindication to MRI examination
* Age between 18 and 35 years-old
* Visual acuity permitting normal perception of stimuli or corrected sight
Exclusion Criteria:
* Existence of a pathology incompatible with the protocol : Heart, respiratory, haematological, caner, neurological disorder...
* Brain-modulating medical treatment
* Alcohol intake before examination
* Uncorrected visual disorder
* Cognitive deficit (criterion MMSE \< 27)
* People protected by articles L1121-5 to L1121-8 of the CSP (pregnant women, under-18 subjects, people under judiciary or administrative surveillance)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Hippocampal activity during behavioural tasks in the MRI scanner
Timeframe: through study completion, an average of 1 year