Prospective Study of Immune Alterations in Operable Breast and Ovarian Carcinoma

Inclusion Criteria: * I1. Female patients aged ≥ 18 tears at time of inform consent signature. * I2. Patient with planned primitive tumor surgery listed below : High grade serous ovarian carcinoma (cohort A), Breast carcinoma SBR grade II or III \> 3 cm (cohort B), Extended breast carcinoma In situ associated with invasive nodule carcinoma macroscopically visible and eligible to mastectomy (cohort C). Note : Patients previously treated by neoadjuvant chemotherapy are eligible and all chemotherapies are authorized. * I3. Patient should understand, sign, and date the written voluntary informed consent form prior to any protocol-specific procedures and should be willing to comply procedures required per protocol. * I4. Patient must be covered by a medical insurance. Exclusion Criteria: * E1. Patient under guardianship or trusteeship. * E2. Cancer with constitutional BRCA1/2 mutation. * E3. Previously treated by immunomodulators (PD1/PDL1, CTLA4). * E4. Systemic treatment by an immunosuppressor (including, but not limited to, corticosteroids, azathioprine, methotrexate, thalidomide and anti-TNF-alpha) or by an immunostimulant within 2 weeks before inclusion, except corticosteroids listed below: inhaled corticosteroids, intranasal corticosteroids, topic corticosteroids, and systemic corticosteroids with prednisone or equivalent physiological dose ≤ 10 mg/day. * E5. Patient with known history of autoimmune disease including, but not limited to, myasthenia gravis, myositis, aut…