Low Dose Prednisone Therapy in Women With Recurrent Pregnancy Loss

Inclusion Criteria: * Patients with unexplained RPL. * Patients with abnormal immunological profile, including ANA, RF, anti-DNA, antilymphocyte, anticardiolipin, antithyroid and lupus anticoagulant antibodies that have no other clinical manifestation. * Women with three or more pregnancy losses (before 24 weeks of gestation) who referred to the RPL clinic in Soroka hospital. * An age above 25 years. * The women agreed to participate in the study and signed on a consent form. * women with index pregnancy. Exclusion Criteria: * Presence of any genetic impairment, Mullerian anomaly, endocrine or metabolic disorders, or a luteal-phase defect (as determined by a timed endometrial biopsy). * Diabetes mellitus diagnosed by symptoms of diabetes plus random glucose concentration≥ 200mg/dL or fasting plasma glucose≥ 126mg/dL or hemoglobin A1C≥5.8% or 2-h plasma glucose≥ 200mg/dL during an oral glucose tolerance test. * Previously untreated tuberculosis, as determined by an abnormal chest film in the previous year or a positive tuberculin skin test. * Prednisone therapy during pregnancy for other reasons. * Sensitivity to prednisone.