Toxins Removal and Inflammatory State modulAtion During Online Hemodiafiltration: Comparison of Two Different Dialyzers

Inclusion Criteria: * Patients with chronic renal failure under periodic standard bicarbonate hemodialysis; * Three times a week dialysis session; * Residual diuresis \<200 mL/day; * Age \>18 years; * Vascular access for hemodialysis with blood flow \>250 mL/minute; * Need of on-line hemodiafiltration (HDF) for signs of middle molecules intoxication (e.g. B2M \>30 mg/L, peripheral neuropathy, cardiovascular comorbidities) or for intradialytic hypotension. Exclusion Criteria: * Acute coronary syndrome; * Acute hemorrage; * Enrollment in another study protocol; * Active infection; * Malignancy; * Inability to provide written signed consent to participate in the study.