Active — Not RecruitingNot Applicable

Aquaporin-4 Single Nucleotide Polymorphisms in Patients With Idiopathic and Familial Parkinson's Disease

United Kingdom800 participantsStarted 2018-11-28

Plain-language summary

The purpose of this study is to understand the relationship between problems in sleep, genetic variations in the Aquaporin-4 gene (AQP4), and the development of Parkinson's Disease.

Who can participate

Age range18 Years – 85 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 18-85 years of age * Able to give informed consent * Able to perform online neuropsychological examinations * Diagnosis of PD according to Brain Bank Criteria * No presence or personal or family history of other neurological or psychiatric disorders Exclusion Criteria: * Presence of other neurological disorders and known intracranial co-morbidities such as stroke, haemorrhage, space-occupying lesions * Inability to perform online neuropsychological assessment * Inability to have access to informatics technology to perform the online assessment tests * Inability to travel for the assessments * Native language different from English

What they're measuring

Association between genetic variations in the AQP4 gene and worse motor symptoms in PD patients

Timeframe: Up to 36 months

Association between genetic variations in the AQP4 gene and worse cognitive symptoms in PD patients

Timeframe: Up to 36 months

Association between genetic variations in the AQP4 gene and worse sleep symptoms in PD patients

Timeframe: Up to 36 months

Association between genetic variations in the AQP4 gene and worse non-motor symptoms in PD patients

Timeframe: Up to 36 months

Trial details

NCT IDNCT04553185

SponsorUniversity of Exeter

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-12-31

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