2DR Versus 3DR in a Prospective Randomized Controlled Switch Trial

Inclusion Criteria: * Age = or \>18 years. * Ability and willingness to provide written informed consent. * Ability to attend the complete schedule of assessments and patient visits. * Ability and willingness to have blood samples collected and stored indefinitely and used for various research purposes. * HIV RNA \< 50 copies/mL for at least 3 months on a 2nd generation INSTI based regimen. * Females of childbearing potential should be on effective contraception Exclusion Criteria: * Current presence of opportunistic infection (AIDS defining events as defined in category C of the CDC clinical classification). * Evidence of active HBV infection (Hepatitis B surface antigen positive or HBV viral load positive in the past and no evidence of subsequent seroconversion (seroconversion= HBV antigen or viral load negative and positive HBV surface antibody). * Evidence of active HCV infection: HCV antibody positive result within 60 days prior to study entry with positive HCV viral load or, if the HCV antibody result is negative, a positive HCV RNA result within 60 days prior to study entry. * Pregnancy or breastfeeding. * Patients unable to understand the study protocol or any other condition that in the investigator's opinion may compromise compliance with the study protocol * Decompensated liver cirrhosis (Child-Pugh B/C) * Unstable liver disease (as defined by the presence of ascites, encephalopathy, coagulopathy, hypoalbuminemia, esophageal or gastric varices, or persistent jau…