Active — Not RecruitingNot Applicable

Comparison of Dimensional Changes After Tooth Extractions Between Xenograft and Allograft

United States12 participantsStarted 2020-10-01

Plain-language summary

To compare dimensional changes in extraction socket of single rooted teeth, 6 months post extraction, when grafted with xenograft versus allograft.

Age range21 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Males or females ≥ 21 years of age
✓. Able to provide informed consent
✓. Good general oral health (no active periodontal disease, absence of hopeless teeth, absence of active caries, absence of acute infections)
✓. Single rooted non molar teeth needing extraction for miscellaneous reasons (since histological analysis is being done, it is essential to harvest bone core biopsies without inclusion of native bone16)
✓. Presence of natural teeth adjacent to the tooth planned for extraction
✓. Absence of acute signs of infection such as pus discharge, fistulous tract and / or abscess in relation to tooth being extracted
✓. Dehiscence type defects of the sockets limited to 2/3rd length of the root

✕. Conditions and circumstances as evaluated by investigator that would prevent completion of study participation
✕. Conditions requiring chronic routine use of antibiotics or steroids
✕. History of leukocyte dysfunction or deficiencies, bleeding disorders, neoplastic disease requiring radiation or chemotherapy, metabolic bone disorder, uncontrolled endocrine disorders, HIV infections
✕. Alcoholism or drug abuse and heavy smokers \>10 cigarettes a day
✕. Simultaneous participation in other studies
✕. Pregnancy - Patients pregnant before the start of the study or patients who become pregnant during the course of the study
✕. Untreated periodontitis, caries or presence of hopeless teeth (other than the one planned for extraction)
✕. Multi rooted teeth

Horizontal and vertical dimensional changes noted on Cone Beam Computed Tomography

Timeframe: 6 months

NCT IDNCT04550689

SponsorUConn Health

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-06-30

Who can participate

Age range21 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Males or females ≥ 21 years of age
✓. Able to provide informed consent
✓. Good general oral health (no active periodontal disease, absence of hopeless teeth, absence of active caries, absence of acute infections)
✓. Single rooted non molar teeth needing extraction for miscellaneous reasons (since histological analysis is being done, it is essential to harvest bone core biopsies without inclusion of native bone16)
✓. Presence of natural teeth adjacent to the tooth planned for extraction
✓. Absence of acute signs of infection such as pus discharge, fistulous tract and / or abscess in relation to tooth being extracted
✓. Dehiscence type defects of the sockets limited to 2/3rd length of the root

✕. Conditions and circumstances as evaluated by investigator that would prevent completion of study participation
✕. Conditions requiring chronic routine use of antibiotics or steroids
✕. History of leukocyte dysfunction or deficiencies, bleeding disorders, neoplastic disease requiring radiation or chemotherapy, metabolic bone disorder, uncontrolled endocrine disorders, HIV infections
✕. Alcoholism or drug abuse and heavy smokers \>10 cigarettes a day
✕. Simultaneous participation in other studies
✕. Pregnancy - Patients pregnant before the start of the study or patients who become pregnant during the course of the study
✕. Untreated periodontitis, caries or presence of hopeless teeth (other than the one planned for extraction)
✕. Multi rooted teeth