CompletedNot Applicable

Characterization of Myocardial Blood Flow During Heat Exposure

Canada80 participantsStarted 2020-08-25

Plain-language summary

The purpose of this study is to determine the increase in myocardial blood flow during heat exposure and how this response is affected by age and coronary artery disease.

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria for Healthy Participants: * Age between 18-40 years or 60-80 years * Non-smoker (≥1 year) * Non-diabetic * Normal kidney function * Body Mass Index \<30 kg/m2 * Resting blood pressure \<140/\<90 mmHg * Resting heart rate \<100 bpm Inclusion Criteria for Participants with Coronary Artery Disease: * Age between 60-80 years old * History of angiographic coronary disease (≥70% arterial diameter narrowing of at least one major epicardial coronary artery) and/or prior coronary revascularization and/or documented prior acute coronary syndrome and/or perfusion defect during stress testing * Stable medications (≥4 weeks) prior to enrollment Exclusion Criteria for Healthy Participants: * Diagnosis of heart, vascular, respiratory, neurological or metabolic disease and/or a prescription of medication for the treatment of these diseases * Pregnancy or lactation * Dyslipidemia not controlled by medication Exclusion Criteria for Participants with Coronary Artery Disease: * Recent hospitalization (\<3 months) related to coronary artery disease * Unstable angina (\<3 months) * Recent coronary artery bypass surgery (\<3 months) * Left branch block * Ejection fraction \<40% and/or clinical signs of heart failure * Severe valvular heart disease * Hypertension not controlled by medication * Diabetes not controlled by medication and/or serious complications related to diabetes

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Global myocardial blood flow

Timeframe: Change from baseline to an increase in internal body temperature of 1.5 degrees Celsius, estimated average = 90 minutes

Trial details

NCT IDNCT04549974

SponsorMontreal Heart Institute

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-03-31

View on ClinicalTrials.gov More Hot Weather; Adverse Effect trials

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.