The Effect of Dual Trigger for Final Oocyte Maturation on IVF/ICSI Outcomes in Patients With Suboptimal Ovarian Response

Inclusion Criteria: Patients with poor ovarian response (POR) diagnosis according to the POSEIDON stratification system (as POSEIDON group 1) with following criteria : * Women' age under 35 years; * Previous unexpected poor or suboptimal ovarian response after using conventional protocols (subgroup 1a: \< 4 oocytes ) and (subgroup 1b: 4-9 oocytes retrieved) * Adequate ovarian reserve (antral follicle count ≥5 on menstrual cycle day 2-3; and basal serum AMH ≥ 1.2 ng/ml) Exclusion Criteria: * Ovarian failure including basal FSH above 20 IU/l or no antral follicle by ultrasound examination; * Endometriosis grade 3 or higher; * Severe male infertility (surgical sperm extraction: TESE, PESA) * Body mass index \>30 kg/ m2 * History of uterine surgery as well as sub-mucosal and intramural fibroids greater than 5 cm or uterine polyps * Treatment cycles with pre-implantation genetic diagnosis, blastocyst and donation embryo transfer indications * Cigarette and drug addiction