Study of Morphological, Spectral and Metabolic Manifestations of Neurological Complications in Co… (NCT04546737) | Clinical Trial Compass
CompletedNot Applicable
Study of Morphological, Spectral and Metabolic Manifestations of Neurological Complications in Covid-19 Patients
France21 participantsStarted 2020-09-02
Plain-language summary
Viral pandemics, such as HIV and SARS-Cov-V1, have shown that they can lead to acute and / or delayed neurological complications. At the actual context of the pandemic Coronavirus disease 2019 (COVID-19), neurological manifestations seem to be confirmed since in 85% of COVID-19 patients, present neurological symptoms, including anosmia, ageusia, periorbital pain, dizziness, fatigue, even moderate headache, moderate memory and/or behavioral disorders.
However, these neurological manifestations are not well studied and their radiological features are not well described. It is therefore important to assess these potential neurological complications in COVID-19 patients. To the investigator knowledge, there is no previous study in the literature describing spectral brain changes in COVID + patients. Thus, the goal of this work is to describe the radiological semiology using MRI and particularly Magnetic Resonance Spectroscopic (MRS) biomarkers in the evaluation of acute and / or delayed brain damage in COVID + patients presenting a neurological manifestations that are initially related to the cranial nerves damage.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Major COVID-19 patient (≥18 years old)
* COVID-19 patient presenting at least one the neurological manifestations:
anosmia, ageusia, periorbital pain, dizziness, fatigue, moderate headache, moderate memory and behavioral disorders.
* Patient who have signed an informed consent form for the study
Exclusion Criteria:
* Patient under guardianship or curators or under judicial protection
* Pregnant and breastfeeding women
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study used MRI to look at brain changes in COVID-19 patients — if I've had neurological symptoms after COVID-19, could reviewing my own MRI findings with you help us understand what might be happening in my brain?
2Since this trial is already completed, would it be possible for my doctor to access any published results or data from this study that might be relevant to my situation?
3This study tracked 'spectral and metabolic' changes alongside standard MRI — are there specific advanced imaging tests, like MR spectroscopy, that you think would be worthwhile for me to have given my symptoms?
4The study focused on neurological complications in COVID-19 patients — based on what this research found, are there particular patterns of brain involvement I should know about that might match what I'm experiencing?
5Since this was an observational study rather than a treatment trial, what does it mean for my care — are there treatment trials for COVID-related neurological complications that you'd recommend I look into next?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Variation from baseline of MRI radiological semiology in COVID-19 patients