Improving Understanding of Brain Tumors Through Preservation of Biologically Active Brain Tissue (NCT04545177) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Improving Understanding of Brain Tumors Through Preservation of Biologically Active Brain Tissue
United States18 participantsStarted 2020-09-17
Plain-language summary
Recent experiments are giving researchers insight into the changes (mutations) that occur in an individual brain tumor cell compared to a normal cell. Currently, we do not have enough knowledge about how uniform these changes are throughout a single brain tumor and if different regions of a brain tumor have different groupings of changes. By obtaining multiple samples of the tumor from various regions during surgery, it will allow researchers to better understand these changes, with the hope that they will lead to new discoveries in the diagnosis and treatment of brain tumors.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
--Creatinine OR Measured or calculated creatinine clearance (glomerular filtration rate (GFR) can also be used in place of creatinine or CrCl) ≤ 1.5 × ULN OR ≥30 mL/min for participant with creatinine levels \>1.5 × institutional ULN
--International normalized ratio (INR) OR prothrombin time (PT). Activated partial thromboplastin time (aPTT) ≤ 1.5 × upper limit of normal (ULN) unless participant is receiving anticoagulant therapy as long as PT or aPTT is within therapeutic range of intended use of anticoagulants
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial focuses on preserving and studying live brain tumor tissue from surgery — if I'm already planning surgery for my glioblastoma, is this the kind of study where a sample could be collected at the same time, or would it require anything extra beyond what's already being done?
2The trial is listed as 'active not recruiting,' which means they're no longer accepting new participants — can you tell me whether there are similar tissue banking or tumor biology studies currently open that I might be eligible for?
3Since this study's main goal is to figure out whether collected tumor tissue stays viable enough to study, rather than testing a new treatment, what would participating actually mean for my care — would it change my treatment plan in any way?
4The researchers are measuring how much of the tumor tissue survives the preservation process using a lab technique called flow cytometry — can you explain how results from this kind of biological research might eventually help future glioblastoma patients, even if it doesn't directly benefit me right now?
5Given that this is a tissue research study rather than a treatment trial, would you recommend I also look into active treatment trials for glioblastoma alongside something like this, and if so, which ones might make sense for my specific situation?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Feasibility, as measured by percentage of the sample deemed viable by flow cytometry