TerminatedNot Applicable

IMMPRES: Intraoperative Monitoring & Management to Reduce Stroke

Stopped: Staffing, funding

United States19 participantsStarted 2021-04-20

Plain-language summary

The objective of this study is to prospectively evaluate the therapeutic effectiveness of with blood pressure management using intraoperative neurophysiological monitoring with SSEP and EEG to reduce perioperative stroke. The central hypothesis is that perioperative stroke occurs from emboli in the setting of significant hypoperfusion resulting in ischemia, which leads to infarction. The impact of the proposed research is that, if significant SSEP and EEG changes can be used to identify cerebral perfusion, then timely therapeutic interventions to effectively reduce the impact of perioperative stroke can be directed.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients scheduled for Cardiac surgery at UPMC * Patients who are 18 years of age or older at screening * Patients with the ability to provide written informed consent Exclusion Criteria: * Patient who, as determined by the investigators, are noncompliant or unable to complete follow-up assessments * Patient with history of dementia or other cognitive impairment. History of dementia will be determined by medical record review. * Patients who, as determined by the investigators, are unable to complete the preoperative testing * Have an implanted medical electronic device * Have indwelling or implanted metal in their body that is not MRI-compatible * Have claustrophobia. This will be measured by utilizing the standard screening questionnaire for MRI. * Develop back pain when lying flat for more than 1 hour * Pregnancy

What they're measuring

Proportion of Patients With a New Clinical Stroke, New Overt Stroke, and Death

Timeframe: post-operative day 30

Trial details

NCT IDNCT04543838

SponsorParthasarathy Thirumala

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-01-17

Results submitted2024-06-18