WithdrawnPhase 1

MANP in African Americans With Hypertension

Stopped: Study was withdrawn and replaced by a larger study

United States0Started 2018-05-01

Plain-language summary

Evaluate the cardiovascular properties of MANP in AA with Hypertension

Age range20 Years – 70 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Hypertension, defined as a mean supine BP equal to or greater than 140 mmHg and taking at least one standard of care therapies (including a diuretic, angiotensin converting enzyme inhibitor or angiotensin receptor blocker and a calcium channel blocker);
✓. MDRD estimated GFR \> 30 mL/min to be calculated at the screening visit by available serum creatinine
✓. Male or female African Americans
✓. Have a body mass index (BMI) within the range of 18-40 kg/m2;
✓. Be able to communicate effectively with the study personnel
✓. Be adequately informed of the nature and risks of the study and give written informed consent prior to receiving study medication.

✕. Known hypersensitivity or allergy to MANP or other NPs;
✕. Women of child bearing age
✕. Having received any investigational drug or device within 30 days prior to entry into the study; 4) A history (within the last 2 years) of alcohol abuse, illicit drug use, significant mental illness, physical dependence to any opioid, or any history of drug abuse or addiction;
✕. A history of difficulty with donating blood or donated blood or blood products within 45 days prior to enrollment;
✕. Clinically significant new illness in the 1 month before screening in the opinion of the investigator;
✕. History of severe allergies;
✕. History of CAD, CVD or syncope;
✕. History of epilepsy or other seizure disorder;

Change in Blood Pressure

Timeframe: 12 hours

NCT IDNCT04542681

SponsorMayo Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-12-30

Who can participate

Age range20 Years – 70 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Hypertension, defined as a mean supine BP equal to or greater than 140 mmHg and taking at least one standard of care therapies (including a diuretic, angiotensin converting enzyme inhibitor or angiotensin receptor blocker and a calcium channel blocker);
✓. MDRD estimated GFR \> 30 mL/min to be calculated at the screening visit by available serum creatinine
✓. Male or female African Americans
✓. Have a body mass index (BMI) within the range of 18-40 kg/m2;
✓. Be able to communicate effectively with the study personnel
✓. Be adequately informed of the nature and risks of the study and give written informed consent prior to receiving study medication.

✕. Known hypersensitivity or allergy to MANP or other NPs;
✕. Women of child bearing age
✕. Having received any investigational drug or device within 30 days prior to entry into the study; 4) A history (within the last 2 years) of alcohol abuse, illicit drug use, significant mental illness, physical dependence to any opioid, or any history of drug abuse or addiction;
✕. A history of difficulty with donating blood or donated blood or blood products within 45 days prior to enrollment;
✕. Clinically significant new illness in the 1 month before screening in the opinion of the investigator;
✕. History of severe allergies;
✕. History of CAD, CVD or syncope;
✕. History of epilepsy or other seizure disorder;