CompletedNot Applicable

Driving Pressures in a Closed-loop and a Conventional Mechanical Ventilation Mode

Turkey (Türkiye)26 participantsStarted 2019-08-30

Plain-language summary

In mechanically ventilated patients, driving pressure (ΔP) assess the strain applied to the respiratory system and is related to ICU mortality. The aim of this randomized cross-over trial was to compare ΔP selected by a closed-loop system and by physician tailored mechanical ventilation mode. Pediatric patients admitted to PICU will be enrolled if they were invasively ventilated without any detectable respiratory effort, hemodynamic instability, or significant leakages. Two 60 minute periods of ventilation determined by randomization in APV-CMV and ASV 1.1 will be compared. Settings were adjusted to reach the same minute ventilation in both modes. ΔP will be calculated as the difference between plateau pressure and total PEEP measured using end-inspiratory and end-expiratory occlusion maneuvers, respectively.

Who can participate

Age range1 Month – 18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * All the mechanically ventilated children * between 1-months and 18-years-old * without any detectable respiratory effort * whose clinical condition are not foreseen to change within the next 3 hours Exclusion Criteria: * septic shock * brain death diagnose, * with a leak equal or more than 40% of the current VT, * receiving extracorporeal membrane oxygenation (ECMO) or targeted temperature management (TTM),

What they're measuring

Driving pressure

Timeframe: at the end of period (60th minute)

Trial details

NCT IDNCT04541199

SponsorDr. Behcet Uz Children's Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-03-31

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