Active — Not RecruitingNot Applicable

Goal Management Training for Adult Survivors of Childhood Leukemia and Non-Hodgkins Lymphoma With Neurocognitive Sequelae

Norway60 participantsStarted 2020-09-04

Plain-language summary

Survivors of childhood cancer are at risk for developing neurocognitive sequelae. Multiple meta-analyses demonstrate significant deficits in overall intellectual abilities, academic functioning and specific cognitive skills among survivors of childhood cancer treated with intrathecal chemotherapy only and/or cranial irradiation. Preventing neurocognitive deficits is therefore of great importance. Unfortunately, intervention studies for this group of survivors are scarce. The main aim of this randomized controlled trial is to determine the efficacy of Goal Management Training (GMT) as a group-based treatment program for 60 adult survivors of childhood leukemia, and non Hodgkins lymphoma, diagnosed between 1980 and 2017 at an age below 18, with attention and executive function deficits. The participants will be randomized to one treatment group (GMT), and one waitlist condition followed by one active control intervention, the "Brain health workshop" (BHW), which has a psycho-educative approach. The follow-up time from diagnosis will be ≥5 years and the age at survey 18-40 years. The study will expand the knowledge base on treatment factors important in improving cognitive function. Results from this study can be implemented in rehabilitation for the young adult survivors of childhood leukemia, and non Hodgkins lymphoma, which will be of importance for their future educational and work-related functioning.

Who can participate

Age range18 Years – 40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

The Norwegian Cancer Registry will identify participants based on the following criteria: * Acute Lymphoblastic Leukaemia (ALL), Acute Myelogen Leukemia (AML), non Hodgkins Lymphoma diagnosed between 1980 - 2017 * Age when diagnosed \<18 år (0-17years) * Age at survey 18-40 years * Born between 1980 - 2004 * Minimum five years (≥5) post ALL, AML, NHL diagnosis * ALL, AML, NHL treatment at Oslo University Hospital and St. Olavs Hospital Inclusion Criteria Screening/baseline: * Written informed consent * ≥5 years from diagnosis * Age 18-40 * Without cancer recurrence the last five years * Understand and speak Norwegian Additional inclusion criteria for the intervention: * Experiencing executive dysfunction as determined by a semi-structured interview * Cognitive capacity to engage with the training, and General Ability Index (GAI) Score ≥70 measured by Wechsler Intelligence Scale for Adults (WAIS-IV) Exclusion Criteria: * Cancer recurrence within the last five years * A history of premorbid Central Nervous System (CNS) injury or disease (e.g., Traumatic brain injury with noticeable cognitive changes, loss of consciousness or injury discovered on CT or MR) * Pre-existing attention deficit hyperactivity disorder (ADHD) * Motor or sensory damage impeding study participation * A major psychiatric disease and/or ongoing substance abuse impeding study participation * Present suicidal ideation * Down syndrome

What they're measuring

The Behavior Rating Inventory of Executive Function, Adult (BRIEF-A)

Timeframe: 6 months

Trial details

NCT IDNCT04541056

SponsorNorwegian University of Science and Technology

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-02