Serial MR Imaging and MR Spectroscopic Imaging for the Characterization of Lower Grade Glioma

Inclusion Criteria: * For patients in cohort 1: histologically proven lower grade glioma who are being followed with surveillance scans * For patients in cohort 2: histologically proven glioma who are scheduled for treatment due to suspected residual or recurrent tumor * Patients with a life expectancy \> 12 weeks * Patients must have a Karnofsky performance status of \>= 60 * Patients must have adequate renal function (creatinine \< 1.5 mg/dL) before imaging. These tests must be performed within 60 days prior to the hyperpolarized imaging scan. * Patients must not have any significant medical illnesses that in the investigator's opinion cannot be adequately controlled with appropriate therapy, would compromise the patient's ability to participate in this study or any disease that will obscure toxicity or dangerously impact response to the imaging agent. * Patients must not have New York Heart Association (NYHA) grade II or greater congestive heart failure * Patients must not have history of myocardial infarction or unstable angina within 12 months prior to study enrollment * This study was designed to include women and minorities, but was not designed to measure differences of intervention effects. Males and females will be recruited with no preference to gender. Minorities will actively be recruited to participate. No exclusion to this study will be based on race * Patients must sign an informed consent indicating that they are aware of the investigational nature of this s…