BonE and Joint Infections - Simplifying Treatment in Children Trial

Exclusion criteria

• ✕. Infection due to bacteria resistant to cefalexin or atypical infection (e.g. mycobacterial, fungal)
• ✕. Features of sepsis as defined by the presence of organ dysfunction (defined using definitions within the Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score)
• ✕. Concomitant severe, invasive infection e.g. necrosing fasciitis
• ✕. Complicated infection (e.g. presence of prosthetic material; large subperiosteal (\>3mm) or soft tissue abscess without surgical intervention; infection secondary to or complicated by trauma)
• ✕. History of allergy to cephalosporin antibiotics or immediate, severe reaction to penicillins
• ✕. Received more than three IV or oral dose of an antibiotic with activity against the likely bacteria causing the current infection
• ✕. Prior episode of OM or SA
• ✕. Prior condition predisposing to poor absorption (e.g. inflammatory bowel disease, current gastrointestinal symptoms) or complicated disease (e.g. immunodeficiency)