Effects of Topical Low Dose Preservative-free Hydrocortisone on Intraocular Pressure

Inclusion Criteria: * age of at least 18 years * diagnosis of OSD (Ocular Surface Disease) * normal ophthalmic findings except history of OSD for at least 3 months, and current therapy with topical lubricants for at least 3 months * POAG (primary open-angle glaucoma ) patients on medical therapy Exclusion Criteria: * clinically significant slit lamp findings at screening visit except OSD * participation in a clinical trial in the 4 weeks preceding the screening visit * symptoms of a clinically relevant illness in the 3 weeks before the screening visit * presence/ history of a severe medical or surgical condition * intake of parasympathomimetic or antipsychotic drugs * wearing of contact lenses * previous refractive laser surgery (e.g photorefractive keratectomy-PRK, laser assisted in situ keratomileusis-LASIK, etc.) * history of IOP increase caused by systemic or topical treatment with corticosteroids * IOP greater than 22 mmHg * treatment with corticosteroids in the 4 weeks preceding the study * types of glaucoma other than POAG * ocular infection or clinically significant inflammation * ocular surgery in the 3 months preceding the study * Sjögren's syndrome, Stevens-Johnson syndrome * history of allergic conjunctivitis * pregnancy, planned pregnancy or lactating * known hypersensitivity to any component of study medication