RecruitingNot Applicable

Effect of Acupuncture on IVF Pregnancy Outcomes for Women With RIF

China771 participantsStarted 2020-11-02

Plain-language summary

The randomized, placebo-controlled multicenter trial is conducted in five centers in China. After screening and obtaining the signed informed consent , the participants are randomly divided into three groups: acupuncture group (Acu.+IVF），sham acupuncture group（Sham Acu. +IVF），and the control group (only IVF).

Who can participate

Age range25 Years – 40 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Married women aged 25-40;
✓. Repeated implantation failure for unknown reasons (experienced 2 or more embryo transfers of good-quality embryos without achieving clinical pregnancy);
✓. Transplantable Day 3 high-quality frozen embryos or frozen blastocysts (≥3BB);
✓. Estrogen and progesterone replacement therapy (HRT), endometrial thickness ≥7mm on the day of endometrial transformation.

Exclusion criteria

✕. Those who prepare for PGD;
✕. Recipients of egg donors;
✕. Chromosomal abnormalities in both or one of the couples (excluding chromosome polymorphism);
✕. patients with implantation failure due to known embryonic factors;
✕. Uterine lesions that may affect implantation (including uterine malformation, \>4cm intramural fibroids，submucosal fibroids, adenomyosis, uterine tuberculosis, intrauterine adhesions, etc.
✕. Repeated spontaneous abortion (2 or more fetal loss before 28 weeks of gestation);
✕. Patients with other endocrine diseases, such as thyroid disease, hyperprolactinemia, insulin resistance, diabetes, adrenal disease, etc., and poor control of hormone levels in the last 3 months;
✕. Clearly diagnosed autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, etc.;

What they're measuring

CPR

Timeframe: 1 year

Trial details

NCT IDNCT04533295

SponsorHuazhong University of Science and Technology

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-11-30

Contact for this trial

Cuihong Zheng, professor

86-27-83663275 chzheng@tjh.tjmu.edu.cn

View on ClinicalTrials.gov More Repeated Implantation Failure trials