TerminatedPhase 2

Microbiological Evaluation of Single Versus Multiple Visits Regeneration Using MALDI-TOF Mass Spectrometry

Stopped: due to the COVID-19 pandemic

Egypt16 participantsStarted 2018-08-23

Plain-language summary

Aim of the study is to assess canal disinfection using matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) in single visit and multiple visit regeneration protocols, and to assess clinical and radiographic outcomes of single visit and multiple visit regeneration protocols.

Who can participate

Age range

8 Years – 18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Immature permanent upper anterior teeth. * Necrotic teeth confirmed by sensibility test. * Teeth with periapical lesions confirmed by periapical radiograph using paralleling device. Exclusion Criteria: * Teeth with orthodontic wires or brackets. * Patient with history of allergy to any medication. * Patient with history of bleeding disorders. * Patient with medical illness or taking medications.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Microbiological assessment

Timeframe: 24 hours

Tooth vitality

Timeframe: up to 12 months

Tooth mobility

Timeframe: up to 12 months

Healing of periapical lesions

Timeframe: up to 12 months

Root lengthening

Timeframe: up to 12 months

Root thickening

Timeframe: up to 12 months

Trial details

NCT IDNCT04533074

SponsorNourhan M.Aly

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-03-10

View on ClinicalTrials.gov More Pulp Necroses trials

Plain-language summary

Who can participate

Age range

8 Years – 18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.