RecruitingNot Applicable

Transcranial Magnetic Stimulation for Restricted and Repetitive Behavior in ASD

United States67 participantsStarted 2021-01-04

Plain-language summary

Investigating the efficacy of a form of TMS called theta-burst stimulation for restricted and repetitive behavior in ASD.

Age range12 Years – 45 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Diagnosis of Autism Spectrum Disorder (ASD)
✓. Meet criteria for Autism Spectrum Disorder (ASD) on clinical assessments (ADOS-2 or CARS if conducted remotely \& ADI-R)
✓. Aged between 12-45 years old
✓. Have a reliable informant who can complete relevant questionnaires
✓. Have DARB scores which indicate high levels (50% or above) of RRB on one of the following domains: Insistence on Sameness, Obsessive Compulsive Behaviors, and Unusual Interests

✕. Any contraindications for TMS e.g. history of seizures other than clear substance-induced/fever-induced seizures with neurologist note or normal clean EEG and no seizure in at least 12 months prior to enrollment.
✕. Pregnancy.
✕. Any current or past history of any physical condition which in the investigator's opinion might put the subject at risk or interfere with study results interpretation.
✕. Active substance use (\<1 week) or intoxication verified by toxicology screen--of cocaine, amphetamines, benzodiazepines.
✕. Showing symptoms of withdrawal from alcohol or benzodiazepines.
✕. DSM-5 diagnosis of bipolar disorder or a psychotic disorder e.g. schizophrenia.
✕. Significant sensory impairments such as blindness or deafness.
✕. Current severe insomnia (must sleep a minimum of 4 hours the night before stimulation).

Repetitive Behavior Scale-Revised (RBS-R)

Timeframe: Up to one month post-treatment

NCT IDNCT04532424

SponsorStanford University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-12-01

Briana Hernandez

Who can participate

Age range12 Years – 45 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Diagnosis of Autism Spectrum Disorder (ASD)
✓. Meet criteria for Autism Spectrum Disorder (ASD) on clinical assessments (ADOS-2 or CARS if conducted remotely \& ADI-R)
✓. Aged between 12-45 years old
✓. Have a reliable informant who can complete relevant questionnaires
✓. Have DARB scores which indicate high levels (50% or above) of RRB on one of the following domains: Insistence on Sameness, Obsessive Compulsive Behaviors, and Unusual Interests

✕. Any contraindications for TMS e.g. history of seizures other than clear substance-induced/fever-induced seizures with neurologist note or normal clean EEG and no seizure in at least 12 months prior to enrollment.
✕. Pregnancy.
✕. Any current or past history of any physical condition which in the investigator's opinion might put the subject at risk or interfere with study results interpretation.
✕. Active substance use (\<1 week) or intoxication verified by toxicology screen--of cocaine, amphetamines, benzodiazepines.
✕. Showing symptoms of withdrawal from alcohol or benzodiazepines.
✕. DSM-5 diagnosis of bipolar disorder or a psychotic disorder e.g. schizophrenia.
✕. Significant sensory impairments such as blindness or deafness.
✕. Current severe insomnia (must sleep a minimum of 4 hours the night before stimulation).