CompletedNot Applicable

Probiotics and Antibiotic Associated Diarrhea in Pediatric Complicated Appendicitis

United States98 participantsStarted 2020-09-08

Plain-language summary

To determine the effectiveness of the use of probiotics in patients with a diagnosis of complicated appendicitis on antibiotic associated diarrhea (AAD). Probiotics are defined as live microbial organisms that when administered in sufficient amounts, can provide a protective benefit to the individual patient. The use of probiotics in a pediatric population exposed to antibiotics and gastrointestinal surgery such as an appendectomy may provide a protective effect and prevent antibiotic associated diarrhea (ADD)

Who can participate

Age range4 Years – 18 Years

SexALL

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Inclusion criteria

✓. Patients with a post-operative diagnosis of complicated appendicitis who undergo an immediate appendectomy.
✓. Patients between the ages of 4 and 18 years of age.

Exclusion criteria

✕. Patients diagnosed with an complicated appendicitis with deferred appendectomy or non-perforated appendicitis
✕. Patients that have a history of being immunosuppressed, on immunosuppression therapy, or long-term steroid therapy within the last month.
✕. Patients that have central line access.
✕. Patients under 4 years of age.
✕. Patients that are developmentally delayed and cannot ambulate at baseline.
✕. Patients with significant past medical history.
✕. Patients that are in Child Protective Services custody.
✕. Patients that are incarcerated.

What they're measuring

Length of Hospital Stay

Timeframe: From admission to discharge, up to 1 month

Trial details

NCT IDNCT04529980

SponsorChildren's Health

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-02-28

Results submitted2023-06-12

View on ClinicalTrials.gov More Appendicitis trials