PNEUMA is a preliminary safety and feasibility trial of a novel approach to the titration of neuromuscular blockade (NMB) to safe spontaneous breathing in patients with moderate to severe acute hypoxemic respiratory failure (AHRF) supported with invasive mechanical ventilation.
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Rate of patients achieving and maintaining targeted expiratory occlusion pressure (Pocc)
Timeframe: Assessed for 48 hours after study intervention initiation