Misfolded Proteins in the Skin of People With Parkinson's Disease and Other Parkinsonism

Inclusion Criteria: * Age 21 years old and age \<90 years of age at the time of the baseline visit 1 * Age of diagnosis at least 40 years old for PD, DLB, and PSP and at least 30 years old for MSA * A confirmed diagnosis of PD, PSP, CBD, MSA, DLB, or healthy control * Montreal Cognitive Assessment (MoCA) \> 10 at the outset of the study Exclusion Criteria: * Age 90 or above * Allergy to local anesthetic * History of deep brain stimulation (DBS) or other brain surgery prior to Visit 1 * For PD or DLB diagnoses, any other neurodegenerative or central nervous system process that would interfere with examination * For PD or DLB, history of negative DATscan * Use of investigational drugs or devices within 60 days prior to baseline visit (except for dietary supplements) * In control subjects, family history of a neurodegenerative disease in a first degree or second degree blood relative * History of schizophrenia * History of antipsychotic medication use or exposure in controls or history of antipsychotic medication leading to parkinsonism (drug induced parkinsonism) in the parkinsonism group * Blood clotting disorder * On multiple (more than one) antiplatelet and/or anticoagulant blood thinner medications in combination (except for aspirin if it can be safely held for 1 week) * Any other medical, psychiatric, or cognitive illness that in the investigator's opinion would interfere with cooperation or ability to undergo the study procedures.