CompletedNot Applicable

CPAP in AF Patients With OSA

Taiwan25 participantsStarted 2020-08-07

Plain-language summary

Obstructive sleep apnea is associated with atrial fibrillation. This study is to evaluate the effect of continuous positive airway pressure on the burden of atrial fibrillation in the patients with obstructive sleep apnea and paroxysmal atrial fibrillation.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. men or women aged 18 to 80 years
✓. paroxysmal AF, diagnosed based on the ACC/AHA/HRS 2014 guideline, and is defined as AF that terminates spontaneously or with intervention within 7 d of onset either by 12-lead EKG, 24-hr Holter, or 14-day ECG monitor.
✓. OSA, defined as an AHI\>15/hr of sleep, of which \>50% of events are obstructive.
✓. Informed consent signed

Exclusion criteria

✕. Moderate-severe valvular heart diseases (regurgitation or stenosis)
✕. post heart surgery
✕. Uncontrolled systemic hypertension or pulmonary hypertension
✕. Use of psychoactive or other drugs that could influence breathing patterns
✕. Current use of CPAP treatment
✕. Epworth sleepiness scale\>10
✕. Congestive heart failure (LVEF≦45%)
✕. Chronic obstructive pulmonary disease

What they're measuring

Change of AF burden

Timeframe: 0, 6, 12 months

change of left atrium volume

Timeframe: 0, 6, 12 months

change of Quality of Life

Timeframe: 0, 6, 12 months

Number of participants hospitalized for cardiovascular or all causes

Timeframe: 12 months

Trial details

NCT IDNCT04513483

SponsorNational Taiwan University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-08-06

View on ClinicalTrials.gov More Atrial Fibrillation trials