Valproate Alone or in Combination With Quetiapine for Severe COVID-19 Pneumonia With Agitated Delirium

Inclusion Criteria: * Signed Informed Consent Form by his or her legal/authorized representative * Age ≥ 18 years at time of signing Informed Consent Form * Ability to comply with the study protocol, in the investigator's judgement * Hospitalized with COVID-19 pneumonia confirmed with World Health Organization (WHO) criteria (including an RNA test of any specimen, e.g. respiratory, blood, urine, stool, other bodily fluid) and evidence by chest X-ray or CT scan * Fraction of inspired oxygen (Fi02) ≤ 0.40 and positive end-expiratory pressure (PEEP) ≤8 OR Fi02 ≤ 0.50 and PEEP ≤5 * Fi02 and PEEP ≤ values of previous day * Patient has acceptable spontaneous breathing efforts (may decrease vent rate by 50% for 5 minutes to detect effort.) * No neuromuscular blocking agents or blockade. * RASS score initially at -3 ≤, rising to 3+ after initial attempt to wean from standard of care sedating medications * Other investigational interventions may be permitted Exclusion Criteria: * Known severe allergic reactions to valproate or quetiapine * History of hepatic encephalopathy or end-stage liver disease (Childs-Pugh class B or worse) * Alcohol, or history of alcohol/substance dependence prior to admission * Hx of dementia * Treatment with an antipsychotic agent in the 30 days before ICU admission * Baseline QT duration corrected (QTc) interval ≥ 500 msecs * Pregnancy * Suspected active bacterial, fungal, viral, or other infection (besides COVID-19) * In the opinion of the investigator,…