Inflammatory bowel disease (IBD), including Crohn's disease (CD), Ulcerative Colitis (UC) and IBD-unclassified (IBD-U) is a chronic inflammatory intestinal disorders that affect both children and adults. Patients with IBD can present with severe gastrointestinal symptoms, require frequent hospitalizations, expensive medical treatments and can develop invalidating complications requiring surgery. The incidence of IBD is increasing worldwide. The pathogenesis is multifactorial with immunological, environmental and genetic factors contributing to the disease. There is evidence that oxidative stress (OS) imbalance is involved in IBD onset and evolution, although the exact contribution to the pathogenes is unclear. An antioxidant dietetic approach is promising as an adjunctive treatment of IBD. The main aims of this project are to characterize the OS imbalance in IBD in relation to disease's features and to genetic factors and to evaluate the efficacy of an antioxidant dietetic treatment
Age range
6 Years – 80 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Blood levels of ROS and glutathione in patients with IBD and controls
Timeframe: Baseline
Total antioxidant capacity (Trolox equivalent and ferrous equivalent) in patients with IBD and controls
Timeframe: Baseline
Antioxidant enzymes pattern (GST, SOD, GPxs, GR enzyme levels, activity and transcripts) in patients with IBD and controls
Timeframe: Baseline
Plasma hydroperoxides and thiobarbituric acid reactive species in patients with IBD and controls
Timeframe: Baseline
Urine oxidized guanines (8-OHdG, 8-OHG e guanosine) levels in patients with IBD and controls
Timeframe: Baseline