Intravitreal Bevacizumab for Nonproliferative Diabetic Retinopathy

Inclusion Criteria: * Presence of severe NPDR with DRSS score more than 53 with or without diabetic macular edema * Diagnosis of DM (type 1 or 2) with age more than 18 years' old * Visual acuity from 20/25 to 20/40 according to Snellen chart examination or more than 69 letters according to ETDRS chart Exclusion Criteria: * Presence of proliferative diabetic retinopathy features including vitreous hemorrhage or optic disc or retinal neovascularization * History of retinal laser photocoagulation * Tractional retinal detachment involving the macula * Evidence of neovascularization of angle on examination * Macular edema due to a cause other than DME * Any ocular condition which may change visual acuity during the study * History of intravitreal injection of anti-vascular endothelial growth factor agent in past 3 months * History of any use of intravitreal corticosteroid * History of major intra-ocular surgery except cataract surgery in the past 6 months * History of thromboembolic every in the past 3 months