CompletedNot Applicable

Noninvasive Brain Stimulation on Memory in Individuals With Mild Cognitive Impairment and History of Brain Injury

United States26 participantsStarted 2020-12-05

Plain-language summary

The study will examine the efficacy of high definition transcranial direct current stimulation (HD-tDCS) and its influence on episodic memory in patients with amnestic mild cognitive impairment and a history of Traumatic brain injury. Ten sessions of HD-tDCS to the dorsal anterior cingulate region is expected to result in improvements in episodic memory measures immediately following the last session and at a 3-month follow-up.

Who can participate

Age range

50 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 50 and older * Native English speakers * 12 years of education or higher * Active diagnosis of aMCI * History of TBI based on VA/DOD criteria Exclusion Criteria: * TBI within the past 2 years * Lifetime history of stroke, transient ischemic attack, heart attack, or congestive heart failure * Lifetime history of epilepsy * Major psychiatric disorders (i.e., posttraumatic stress disorder, bipolar disorder, schizophrenia) * Substance use disorder * Has metal fragments in head * Taking medications that may interact with the HD-tDCS effect (i.e., amphetamines, L-dopa, carbamazepine, sulpiride, pergolide, lorazepam, dextromethorphan, D-cycloserine, flunarizine, or ropinirole)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Hopkins Verbal Learning Test-Revised Total Learning

Timeframe: Baseline, immediately following last HD-tDCS session, and again at 3-month follow-up

Hopkins Verbal Learning Test-Revised Delayed Recall

Timeframe: Baseline, immediately following the last HD-tDCS session, and a 3-month follow-up

Brief Visuospatial Memory Test-Revised (BVMT-R) Total Learning

Timeframe: Baseline, immediately post-treatment, and a 3 -month follow-up

Brief Visuospatial Memory Test-Revised Delayed Recall

Timeframe: Baseline, immediately post-treatment, and a 3-month follow-up

Trial details

NCT IDNCT04504630

SponsorUniversity of Texas Southwestern Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-06-16

Results submitted2025-03-27

View on ClinicalTrials.gov More Amnestic Mild Cognitive Impairment trials