The objective of the current study is to compare non-healing colonic ulcers in patients with inflammatory bowel disease (IBD) with iatrogenic colonic ulcers (biopsy sites) in healthy control patients and patients with rheumatoid or psoriatic arthritis. Patients will be biopsied at baseline and again at a follow-up visit in a "biopsy of the biopsy" approach. These biopsies will be used to reveal patterns about gene expression and mitochondrial function during ulcer healing.
Age range
18 Years – 90 Years
Sex
ALL
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Change in mitochondrial DNA copy number
Timeframe: 35 days
Change in expression levels of cMyc
Timeframe: 35 days
Change in expression levels of PGC-1 alpha
Timeframe: 35 days
Change in expression levels of Ki67
Timeframe: 35 days
Number of visible ulcers
Timeframe: 1 day (at follow-up visit)