Regulation of Mucosal Healing in Inflammatory Bowel Disease

Inclusion Criteria (Group 1): * Diagnosed ulcerative colitis or Crohn's disease * Biologic failure or naive to biologic treatment * Eligible to be treated with anti-TNF therapy Inclusion Criteria (Group 2): * Diagnosed rheumatoid or psoriatic arthritis * Receiving anti-TNF antibody therapy at the time of enrollment Inclusion Criteria (Group 3): * Endoscopically unremarkable colonic mucosa * Absence of inflammatory bowel disease Exclusion Criteria: * Classified in an anesthesia risk group, ASA Class =4 * History of bleeding diathesis or coagulopathy * Stroke or transient neurological attack with the last 6 months * Pregnant * Receiving anticoagulants or anti-platelet medications other than low-dose aspirin * Receiving steroid therapy or metformin * HIV positive * Incarceration * History of total proctocolectomy * History of system chemotherapy within 18 months * Uncontrolled intercurrent illness