MMP-9 Inhibition for Recalcitrant Wet AMD

Inclusion Criteria: * Wet age-related macular degeneration (wAMD); * Solely treated with anti-VEGF IVI for active CNV due to wAMD. However, enrolled patients can have other retinal pathologies such as diabetic retinopathy or vein occlusion for which they are not being treated with anti-VEGF IVI; * Must have persistent sub-retinal with or without intra-retinal fluid due to active CNV from wAMD despite receiving at least three consecutive injections with any anti-VEGF agent; * Must not have encountered previous side effects from tetracycline medications. Exclusion Criteria - Ocular: * History of uveitis (including endophthalmitis) or presence of intraocular inflammation; * Presence of significant epiretinal membrane or macular hole causing distortion of macular anatomy; * Presence of media opacity preventing discerning of fluid on OCT; * Any prior ophthalmic surgery (including YAG or retinal laser) within the previous 3 months or anticipated need for any ophthalmic surgery (including cataract extraction) for 9 months following randomization; * History of peribulbar corticosteroid injection to the studied eye or the fellow eye within the past 6 months; * History of intravitreal triamcinolone acetonide injection to the studied eye within the past 4 months; * An ocular condition (other than AMD) is present in the studied eye that, in the opinion of the investigator, might alter visual acuity during the course of the study (e.g., retinal vein occlusion, uveitis or other ocular i…