Olanzapine for the Prevention of Chemotherapy Induced Nausea and Vomiting in Gynecologic Oncology Patients

Inclusion Criteria: * Diagnosis of gynecologic malignancy * No chemotherapy in the last 12 months * Scheduled to receive Carboplatin (AUC\>=4) and Paclitaxel every three weeks * ECOG performance status 0 or 1 * English speaking * Willing and able to provide informed consent * Laboratory values within protocol-defined parameters * No vomiting in the 24 hours prior to initiating chemotherapy * If childbearing potential exists, negative pregnancy test within 7 days prior to registration Exclusion Criteria: * Significant cognitive compromise * History of CNS disease (e.g. brain metastases, seizure disorder, dementia) * Current or recent (within 30 days) treatment with another antipsychotic agent (antidepressant medications are OK) * Concurrent radiotherapy treatment * Known hypersensitivity to olanzapine * Known cardiac arrhythmia, uncontrolled congestive heart failure or acute myocardial infarction within the last six months * History of diabetes mellitus on medication (insulin or oral glycemic agent) * Alcohol abuse / chronic alcoholism * History of closed angle glaucoma * Current enrollment in other clinical trials