High-level Laser for Provoked Vestibulodynia

Inclusion Criteria: * Moderate to severe pain (≥5/10) during sexual intercourse for at least 3 months * Moderate to severe pain (≥5/10) in at least 90% of sexual intercourses or attempted sexual intercourse for at least 3 months * Provoked vestibulodynia lasting at least 3 months prior to the study and diagnosed by a standardised gynaecologic exam Exclusion Criteria: * Other causes of vulvo-vaginal pain (e.g. spontaneous vulvovaginal pain not related to sexual intercourse/contact, dermatological condition, herpes, vulvo-vaginal atrophy) * Post-menopausal state * Actual or past pregnancy in the last year * Urogynecological condition (e.g. pelvic organs prolapse ≥3, urinary/vaginal infection active or in the last 3 months) * Anterior vulvar, vaginal or pelvic surgery (e.g. vestibulectomy, corrective pelvic organs prolapses surgery) * Prior use of laser treatments for vulvar pain * Expected changes of medication that could influence pain perception (e.g. analgesic, antidepressant) * Other medical conditions that could interfere with the study