Near-Infrared Laser Stimulation for Various Neurological Conditions

Inclusion Criteria (depression): * Diagnosis of Major Depressive Disorder * Score greater than 13 on the Beck Depression Inventory * Failure to remit with 3 antidepressants * At least 18 years of age Inclusion Criteria (anxiety): * Diagnosis of Generalized or Acute Anxiety Disorder * Score greater than 22 on the Beck Anxiety Inventory * Failure to remit with 3 anxiolytics * At least 18 years of age Inclusion Criteria (neurodegenerative dementia): * Cognitive decline with mild cognitive impairment (Clinical Dementia Rating stage 0.5) through moderate dementia (CDR stage 2) * Lumbar puncture for Abeta 42 and Tau proteins evincing clinical correlation of neurodegenerative disease pathology * Advanced MRI of the brain including volume measurement of the hippocampus, blood-oxygen level dependent imaging, and arterial spin labeling perfusion scans. On entry, patients will have CDR stage of at least 0.5 and at least one abnormal imaging biomarker. Inclusion criteria (TBI/CTE): * Diagnosis of Traumatic Brain Injury or Chronic Traumatic Encephalopathy * At least 18 years of age Exclusion Criteria: * Macular degeneration * Subjects with scalp rash or open wounds on the scalp (for example from treatment of squamous cell cancer) * Advanced kidney, pulmonary, cardiac or liver failure * Advanced terminal illness * Any active cancer or chemotherapy * Bone marrow disorder * Myeloproliferative disorder * Sickle cell disease * Primary pulmonary hypertension * Immunocompromising condit…