Neurobiological Mechanisms of Stress in Youth With Chronic Widespread Pain

Chronic Widespread Pain (CWP) group: Inclusion Criteria: * Between ages 11-17 years * Referred to the Boston Children's Hospital Pain Treatment Service for evaluation of a CWP condition with duration \> 3 months * Right-handed Exclusion Criteria: * Inability to speak sufficient English to complete questionnaires * Severe cognitive impairment * Prescription steroidal (interference with cortisol measures) or psychotropic medication * Any other chronic pain diagnosis (e.g., migraines, abdominal pain, CRPS) * fMRI contraindications (e.g., dental appliances) Healthy Control (HC) group: Inclusion Criteria: * Between ages 11-17 years * Right-handed Exclusion Criteria: * Inability to speak sufficient English to complete questionnaires * Severe cognitive impairment * Prescription steroidal (interference with cortisol measures) or psychotropic medication * Any chronic pain diagnosis * Presence of documented chronic (\> 3 months) medical condition with an identifiable, organic cause (e.g., diabetes, cystic fibrosis) * fMRI contraindications (e.g., dental appliances)