Penetration of the Innovative Antibiotic Gepotidacin Into Prostate and Tonsillar Tissue

Inclusion Criteria: Cohort A only: * Clinically localized prostate cancer or benign prostate hyperplasia * Male patient scheduled for prostatectomy Cohort B only: * Male or female patient scheduled for complete tonsillectomy * A female participant is eligible to participate if she is not pregnant or breastfeeding, and at least one of the following conditions applies: * Is not a woman of childbearing potential (WOCBP) or * Is a WOCBP with a highly sensitive negative pregnancy test Both Cohorts: * Age: above 18 years * Body weight ≥40 kg and body mass index (BMI) within the range 18.5 - 32.0 kg/m2 * A signed and dated written informed consent form * The subject is able to understand and willing to comply with protocol requirements and timetables, instructions and protocol-stated restrictions * Negative serology (human immunodeficiency virus, hepatitis B-AG and C-AB) at screening * Patient with a social security or health insurance (if applicable according to the local regulation) Exclusion Criteria: Cohort A only: • Any concerns of the investigator or the treating urologists that the participation in the study might impair histological assessment of the prostate tissue such as (but not limited to): lack of representative histology via previous biopsy AND inability to safely insert microdialysis probes in tissue with sufficient distance to the tumor (e.g. large or diffuse tumor, lack of MRI or PET image to locate tumor within the organ). Cohort B only: * Pregnanc…