Injection Regimen Trial of PEG-rhG-CSF During Breast Cancer Chemotherapy

Exclusion criteria

• ✕. Received systemic or local treatment for tumors, including chemotherapy, radiotherapy, and endocrine therapy.
• ✕. A history of malignant tumors within 5 years (except curable skin basal cell carcinoma and cervical carcinoma in situ).
• ✕. The patient has been enrolled in other clinical trials or used other study drugs 30 days before enrollment in this study.
• ✕. Accompanied by uncontrolled lung disease, severe infection, active gastrointestinal ulcer need treatment, coagulopathy, severe uncontrolled diabetes, connective tissue disease or bone marrow function suppression, and other diseases, can not tolerate chemotherapy-related treatments.
• ✕. Two-dimensional echocardiography detection LVEF \<55%.
• ✕. Severe cardiovascular and cerebrovascular diseases within the first 6 months of randomization (eg unstable angina, chronic heart failure, uncontrollable hypertension\> 150/90 mmHg, myocardial infarction, or cerebrovascular accident).
• ✕. NCI peripheral neurotoxicity grade ≥2.
• ✕. Those taking glucocorticoids.