To analyze the effects of altering the time of ingestion of participants' habitual medication (i.e., metformin, statins, ARAII/IACE) and meals around the time of exercise training (exercise fasted or fed) on the improvement of metabolic syndrome factors (hypertension, insulin sensitivity, dyslipidemia, and obesity). There will be a preliminary study of the effects of training "time-of-day" on the primary study outcomes.
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Insulin sensitivity assessed using intravenous glucose tolerance test
Timeframe: 12 months
Post-prandial lipemia assessed by an oral fat tolerance test
Timeframe: 12 months
Blood pressure assessed by ECG-gated automated sphygmomanometer
Timeframe: 12 months
Glycemic control assessed by 24-h continuous interstitial glucose monitoring
Timeframe: 36 months