This phase I trial investigates the development of a new early detection test to reduce racial disparities in endometrial cancer death rates. DNA samples collected from a tampon may be able to be used to detect endometrial cancer. Studying information from focus groups and vaginal samples of African American and white women may help researchers develop a less invasive and painful test to detect endometrial cancer. The purpose of this trial is to perform a demonstration project of tampon self-collection, assess percentage of samples returned; total and endometrial derived DNA quantity and quality, preliminarily test previously validated DNA methylation markers that may discriminate endometrial cancer from normal endometrium in tampon specimens.
Age range
40 Years
Sex
FEMALE
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Differences in views on endometrial cancer (EC) risk between African American and white women and whether the former would be willing to participate in tampon testing (Aim 1)
Timeframe: Up to 12 months
Total deoxyribonucleic acid (DNA) (Aim 2)
Timeframe: Up to 12 months
Endometrial DNA (Aim 2)
Timeframe: Up to 12 months
Detection of EC-specific methylation markers (Aim 2)
Timeframe: Up to 12 months